TANNO ET AL. / 2000
Niacinamide and barrier lipids.
Tanno and colleagues’ research on nicotinamide and outer-skin lipids.
SEE THE EVIDENCE4ZERO1 / Science
Your barrier. Explained.
Understand the four actions, the ingredient research and the delivery technology behind 4ZERO1.
The barrier, in 30 seconds.
The outermost layer of skin combines flattened cells with surrounding lipids. Together, they help regulate water loss and protect against external exposures. Dryness and disruption can affect how skin looks and feels.
Humectants bind water, emollients soften skin, and suitable film-forming ingredients help limit moisture loss. The complete formulation shapes both performance and feel.
Elias · Rawlings & Harding01 / 02 / 03 / 04
4 actions. One tube.
Explore the formula, one action at a time.
Illustrative skin-barrier schematic
Moisture starts here.
Glycerin, panthenol and the Aquaxyl™ sugar complex form part of the formula’s hydration story.
SEE THE EVIDENCESupport your skin’s own barrier lipids.
Niacinamide has been studied for supporting production of lipids found in the outer skin.
SEE THE EVIDENCEHelp keep moisture in.
Emollients and film-forming ingredients contribute to moisturising care and skin feel.
SEE THE EVIDENCEMeet the protective side of the formula.
Explore the film-forming ingredients and antioxidant components, including vitamin E and InfraGuard™.
SEE THE EVIDENCE
1 / CETOSOMES®
Cetosomes®. Delivery, considered.
The delivery system is part of the formula’s design.
4ZERO1 names Cetosomes® technology licensed from Cymbiotics Inc., USA. The referenced patent describes a self-assembling topical carrier system. Explore the technology alongside the complete formula.
EXPLORE THE TECHNOLOGYTechnology reference · US9084818B2
What the research tells us.
An ingredient study’s findings depend on the tested material, dose, vehicle and study conditions. Product-specific findings belong to the finished formula actually tested. A patent describes technology; it is not a product clinical trial.
No finished-product study report has been supplied for this library.
4ZERO1 / Science
Science. With the sources attached.
Read the research behind the ingredients—and see exactly what each source supports.
FLUHR ET AL. / 1999
Glycerin and barrier recovery.
Human research on glycerol after experimentally induced barrier disruption.
SEE THE EVIDENCEGEHRING & GLOOR / 2000
Panthenol and hydration.
A vehicle-controlled human study of dexpanthenol formulations.
SEE THE EVIDENCEThese are studies of ingredients in tested formulations, not clinical results for 4ZERO1.
OPEN THE RESEARCH LIBRARY